Interaction between cyclic adenosine monophosphate and cyclic gunaosine monophosphate in guinea pig ventricular myocardium.

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Interaction between cyclic adenosine monophosphate and cyclic gunaosine monophosphate in guinea pig ventricular myocardium.

The purpose of this study was to examine the mechanisms underlying adrenergic-cholinergic antagonism in ventricular myocardium. Myocardial contractility, cyclic adenosine monophosphate (AMP) levels, and cyclic guanosine monophosphate (GMP) levels were measure in isolated guinea pig ventricles after treatment with various inotropic agents given alone and simultaneously with acetylcholine. Acetyl...

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Interaction between Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate in Guinea Pig Ventricular Myocardium

The purpose of this study was to examine the mechanisms underlying adrenergiccholinergic antagonism in ventricular myocardium. Myocardial contractility, cyclic adenosine monophosphate (AMP) levels, and cyclic guanosine monophosphate (GMP) levels were measured in isolated guinea pig ventricles after treatment with various inotropic agents given alone and simultaneously with acetylcholine. Acetyl...

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An abstract ofthis work appeared in 1976. Clin. Res. 24: 456A. (Abstr.) Dr. Broadus' present address is Division of Endocrinology, Department of Internal Medicine, Yale University, New Haven, Conn. 06510. Received for publication 20 April 1976 and in revisedform 13 June 1977. the validity of the measurements and the expressions employed.

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Cyclic Adenosine Monophosphate and Cardiac

• This review examines critically the evidence bearing on the hypothesis that the positive inotropic effects of catecholamines are mediated by intracellular cyclic adenosine monophosphate (cyclic AMP). The review is selective in several respects. For example, it does not contain extensive discussions about the biochemical actions of cyclic AMP, the enzymes regulating its synthesis and degradati...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1975

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.37.3.309